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產(chǎn)品英文名稱：Anti-EpCAM
產(chǎn)品中文名稱：抗-EpCAM
BD 抗-EpCAM Anti-EpCAM APC (RUO) 347200產(chǎn)品英文介紹：
Catalog Number 347200
Name CD326
Alias EpCAM
Size 100 Tests
Regulatory Status RUO (GMP)
List Price Inquire
Related Molecules EPCAM
Clone EBA-1
Format APC
Isotype IgG1, λ
W.S. No none
W.B. Positive Control none
Molecular Weight none
Reactivity QC Testing : Human
Applications Routinely Tested: Flow cytometry
Clone - Description
Anti-EpCAM is directed against a human epithelial adhesion molecule (EpCAM) that has been identified as a 40-kilodalton (kd) protein in Western Blotting. This antigen is also known as epithelial surface antigen (ESA) and epithelial glycoprotein 2 (EGP-2).The epithelial cells present in non-squamous epithelia and tumors derived from such cells show EpCAM expression. The normal epithelial cells reactive with anti-EpCAM antibodies are those present in the (lower) respiratory tract; the (lower) gastrointestinal tract; tubules in the kidney; the surface epithelium of the ovary; the exocrine and endocrine pancreas; secondary germ cells of ogenic hair follicles; and secretory tubules of sweat glands in the skin, whereas the epidermis is negative. In addition, all epithelial cells in the thyroid and epithelial cells in the thymus show EpCAM expression, while the outer cortex and Hassall’s corpuscles have low expression. In the liver, only the bile ducts appear to be positive with anti-EpCAM antibodies. Non-squamous–carcinoma cells have high EpCAM expression, whereas such expression can also occur in squamous carcinoma. Tumors arising from non-epithelial cells, such as lymphoma, mesothelioma, neuroblastoma, and melanoma, do not express EpCAM.
BD 抗-EpCAM Anti-EpCAM APC (RUO) 347200介紹：
抗EpCAM是針對人上皮粘附分子（EpCAM的）已被確定為蛋白質(zhì)印跡一個40千道爾頓（KD）的蛋白質(zhì)。這種抗原也被稱為上皮表面抗原（ESA）和上 皮糖蛋白-2（EGP-2）。存在于非鱗狀上皮細胞和從這些細胞衍生的腫瘤的上皮細胞顯示EpCAM的表達。正常上皮細胞與抗-EpCAM抗體的反應(yīng)性是 指那些存在于（低級）呼吸道;的（低級）胃腸道;小管在腎;卵巢表面上皮;外分泌和內(nèi)分泌胰腺;的調(diào)聚毛囊二次生殖細胞;和在皮膚汗腺的分泌小管，而表皮 是負的。此外，所有的上皮細胞在胸腺中的甲狀腺細胞和上皮細胞顯示EpCAM的表達，而所述外皮層和哈索爾的微粒具有低的表達。在肝臟中，只有膽管似乎與 抗-EpCAM抗體陽性。非鱗狀癌細胞具有高EpCAM的表達，而這種表達也可以發(fā)生在鱗狀細胞癌。從非上皮細胞，如淋巴瘤，間皮瘤，神經(jīng)母細胞瘤和黑色 素瘤產(chǎn)生的腫瘤，不表達EpCAM。
BD 抗-EpCAM Anti-EpCAM APC (RUO) 347200使用注意事項：
WARNING
Reagents contain sodium azide. Sodium azide is harmful if swallowed. Keep out of reach of children.
Keep away from food, drink, and animal feedingstuff. Wear suitable protective clothing. If
swallowed, seek medical advice immediay and show this container or label. Contact with acids
liberates very toxic gas. Azide compounds should be flushed with large volumes of water during
disposal to avoid deposits in lead or copper plumbing where explosive conditions can develop.
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